TCMS was founded in 1853
In 1951, TCMS members founded what is today We Are Blood, the exclusive non-profit provider of therapeutic blood components and services. Today, We Are Blood provides services to 37 health care facilities in Central Texas. United Tissue Resources (a subsidiary of We Are Blood) provides surgical recovery of tissue from donors for 70 hospitals in Central Texas and surrounding regions.
In 1955, the Society created a subsidiary answering service that today, operating as the Medical Exchange , is a modern, full service call center providing 24/7 coverage for the medical community. 
1963 Polio vaccine distributed by TCMS
1967 TCMS distributes measles vaccines to 25,000 Travis County children
In 1971, the Society established a non-profit Foundation that operated ACGME-accredited community-based graduate medical education (GME) programs until 1998 when program sponsorship was transferred to Seton. In 2016, those community-based programs established by the Society and expanded by Seton became university-based GME programs of the University of Texas at Austin Dell Medical School. 
1990 The TCMS Retired Physicians’ Organization was founded. This group of 100+ members meets monthly for a catered lunch and unique speakers.
The TCMS Foundation in 2002 launched Project Access, a coordinated system of volunteer physician care, hospital care, medications assistance and diagnostic services for low-income, uninsured residents of Travis County.
2002 TCMS partners with Austin School District to provide athletic physicals to underprivileged students allowing them to participate in school activities such as cheer, band and sports. This program continues to this day.
2003 Tort Reform liability protections pass in Texas largely due to TMA and county society advocacy. As part of this tort reform, several limits have been placed on the damages those injured by medical malpractice can receive. Most notably, with a law that took effect in 2003, damages for pain and suffering are now limited to $250,000 in most malpractice cases.
2003 “First Tuesdays”  is launched by the Texas Medical Alliance, organizing “white coat invasions” of the Texas Capitol during legislative years. Participants meet with legislators to emphasize medicine’s position on specific bills—TCMS members actively participate every session.
2017 TCMS launches the Physician Wellness Program, offering physicians and their partners anonymous, free coaching sessions by vetted psychologists to combat rising burn-out and suicide rates. In addition, small group events such as yoga, music and more add to the stress relieving experiences.
2020 During the COVID-19 pandemic, physicians experienced an unprecedented shortage of PPE. Through donation drives, fundraisers and working with the state, TCMS was able to distribute 4 million masks as well as gloves, gowns, sanitizer and more to the physicians of Central Texas.